A minimum of a single death was reported inside a nursing infant who was exposed to substantial amounts of morphine in breast milk since the mom was an ultra-fast metabolizer of codeine.
Codeine may possibly enhance the neuromuscular blocking motion of skeletal muscle mass relaxants and produce an increased degree of respiratory despair.
Because of synergistic adrenergic outcomes of phenylephrine, one of the active components in Promethazine VC with Codeine Oral Answer, the concomitant use of Promethazine VC with Codeine Oral Answer with sympathomimetic amines like epinephrine, amphetamine, phenylpropanolamine, and bronchodilator beta2-adrenoreceptor agonists might end in tachycardia, arrhythmias, critical hypertensive reaction and possible stroke.
When you are using any of those medications: Buprenorphine, butorphanol, nalbuphine, or pentazocine. If you have been informed by your health care provider you are a rapid metabolizer of some medications. If you're breast-feeding. Usually do not breast-feed Whilst you take promethazine and codeine. This is simply not an index of all medication or medical problems that interact with promethazine and codeine. Tell your health practitioner and pharmacist about all your medication (prescription or OTC, natural products, natural vitamins) and health issues. You must Verify to be sure that it's Harmless for you to consider promethazine and codeine with all of your medicine and medical problems. Will not start off, halt, or alter the dose of any drug without checking with your health practitioner. Associated/comparable medications
to your codeine drug label cautioning from prescribing codeine to kids of any age to treat soreness right after operation to get rid of tonsils or adenoids. We also issued Drug Safety Communications in July 2015 and September 2015 warning about the risk of severe respiration complications in a few small children who metabolized codeine and tramadol considerably faster to their Lively sort than typical (identified as extremely-rapid metabolism), creating probably dangerously large levels inside their bodies as well quickly.
The codeine and promethazine in Promethazine VC with Codeine Oral Solution may perhaps raise the frequency of seizures in individuals with seizure Diseases, and will raise the possibility of seizures taking place in other clinical settings involved with seizures.
Promethazine with Codeine Oral Resolution is indicated to the short-term relief of coughs and higher respiratory signs or symptoms website affiliated with allergy or even the frequent cold in people 18 a long time of age and older.
Almost all of the studies, each beneficial and adverse, were being confined by compact sample dimensions, recall bias and lack of data with regards to dose and timing of publicity.
This medication can dry up and thicken mucus as part of your lungs, rendering it more difficult to breathe and obvious your lungs. That will help reduce this impact, drink a lot of fluids unless in any other case directed by your medical doctor.
The subsequent severe adverse reactions are explained, or described in larger detail, in other sections:
The just one situation during which CYP2D6 extremely-immediate metabolizer position was claimed transpired in the 5-12 months-aged youngster from France who was prescribed an individual tramadol dose while in the evening article-adenotonsillectomy and returned for the Health care facility the next morning with opioid intoxication; he was resuscitated.
Use promethazine and codeine as requested by your medical doctor. Study all information supplied for you. Adhere to all Guidelines carefully. Just take with or without foodstuff. Just take with foodstuff if it brings about an upset abdomen.
Examine the Medication Tutorial furnished by your pharmacist Before you begin having codeine/promethazine and every time you obtain a refill. If you have any questions, ask your physician or pharmacist.
The use of Promethazine with Codeine Oral Alternative in clients with acute or significant bronchial asthma within an unmonitored setting or during the absence of resuscitative devices is contraindicated [seeCONTRAINDICATIONS (4)]. Opioid analgesics and antitussives, including codeine, on the list of Energetic substances in Promethazine with Codeine Oral Resolution, should not be Utilized in patients with acute febrile ailment connected with successful cough or in individuals with Serious respiratory condition where interference with capacity to clear the tracheobronchial tree of secretions would have a deleterious impact on the client's respiratory function.